2011 Clinical Issues in HIV Medicine: Recent Advances & Challenges

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Introduction

Evolving Science Improves HIV Clinival Care and Prevention

Authors: Kenneth H. Mayer and Daniel R. Kuritzkes

pp. 3-9

Development of National and Multiagency HIV

Authors: Michael A. Horberg, Judith A. Aberg, Laura W. Cheever, Philip Renner, Erin O'Brien Kaleba, and Steven M. Asch

pp. 10-11

Editorial Commentary: Quality of Care for Patients Infected with HIV

Author: Samuel A. Bozzette

pp. 12-20

A Randomized, Controlled Trial of Raltegravir Intensification in Antiretroviral-treated, HIV infected Patients with a Suboptimal CD41 T Cell Response

Authors: Hiroyu Hatano, Timothy L. Hayes, Viktor Dahl, Elizabeth Sinclair, Tzong-Hae Lee, Rebecca Hoh, Harry Lampiris, Peter W. Hunt, Sarah Palmer, Joseph M. McCune, Jeffrey N. Martin, Michael P. Busch, Barbara L. Shacklett, and Steven G. Deeks

pp. 21-24

Editorial Commentary: Hide and Seek. Can We Eradicate HIV by Treatment Intensification?

Authors: Julian Schulze zur Wiesch and Jan van Lunzen

pp. 25-35

HIV-1 Integrase Inhibitor Resistance and Its Clinical Implications

Authors: Jose-Luis Blanco, Vici Varghese, Soo-Yon Rhee, Jose M. Gatell, and Robert W. Shafer

pp. 36-44

Deep Sequencing to Infer HIV-1 Co-Receptor Usage: Application to Three Clinical Trials of Maraviroc in Treatment-Experienced Patients

Authors: Luke C. Swenson, Theresa Mo, Winnie W.Y. Dong, Xiaoyin Zhong, Conan K. Woods, Mark A. Jensen, Alexander Thielen, Douglass Chapman, Marilyn Lewis, Ian James, Jayvant Heera, Hernan Valdez, and P. Richard Harrigan

pp. 45-47

Editorial Commentary: Genotypic Tests for Determining Coreceptor Usage of HIV-1

Authors: Daniel R. Kuritzkes

pp. 48-54

HIV-1 Viral Escape in Cerebrospinal Fluid of Subjects on Suppressive Antiretroviral Treatment

Authors: Arvid Ede´n, Dietmar Fuchs, Lars Hagberg, Staffan Nilsson, Serena Spudich, Bo Svennerholm, Richard W. Price, and Magnus Gissle´n

pp. 55-56

Editorial Commentary: Viral Escape in Cerebrospinal Fluid An Achilles Heel of HIV Therapy?

Authors: David B. Clifford

pp. 57-67

Bone Mineral Density and Fractures in Antiretroviral-Naive Persons Randomized to Receive Abacavir-Lamivudine or Tenofovir Disoproxil Fumarate-Emtricitabine Along With Efavirenz or Atazanavir-Ritonavir: AIDS Clinical Trials Group A5224s, a Substudy of ACTG A5202

Authors: Grace A. McComsey, Douglas Kitch, Eric S. Daar, Camlin Tierney, Nasreen C. Jahed, Pablo Tebas, Laurie Myers, Kathleen Melbourne, Belinda Ha, and Paul E. Sax

pp. 68-70

Editorial Commentary: Increasing Clarity on Bone Loss Associated With Antiretroviral Initiation

Authors: Michael T. Yin and E. Turner Overton

pp. 71-80

Bone Disease in HIV Infection: A Practical Review and Recommendations for HIV Care Providers

Authors: Grace A. McComsey, Pablo Tebas, Elizabeth Shane, Michael T. Yin, E. Turner Overton, Jeannie S. Huang, Grace M. Aldrovandi, Sandra W. Cardoso, Jorge L. Santana, and Todd T. Brown

pp. 81-83

Editorial Commentary: Low Bone Mineral Density with Tenofovir: Does Statistically Significant Mean Clinically Significant?

Author: Andrew Carr and Jennifer Hoy

pp. 84-96

Low CD41 T Cell Count Is a Risk Factor for Cardiovascular Disease Events in the HIV Outpatient Study

Author: Kenneth A. Lichtenstein, Carl Armon, Kate Buchacz, Joan S. Chmiel, Kern Buckner, E. M. Tedaldi, Kathy Wood, Scott D. Holmberg, and John T. Brooks, for the HIV Outpatient Study (HOPS) Investigatorsa

pp. 97-102

Cancer as a Cause of Death among People with AIDS in the United States

Authors: Edgar P. Simard and Eric A. Engels

pp. 103-110

HAART and Progression to High-Grade Anal Intraepithelial Neoplasia in Men Who Have Sex With Men and Are Infected With HIV

Authors: Alexandra de Pokomandy, Danielle Rouleau, George Ghattas, Helen Trottier, Sylvie Vezina, Pierre Cote John Macleod, Guy Allaire, Rachid Hadjeres, Eduardo L. Franco, and Francxois Coutle´e

pp. 111-112

Editorial Commentary: Anal Intraepithelial Neoplasia in Men Living With HIV in the Era of Highly Active Antiretroviral Therapy

Author: Alberto Severini

pp. 113-116

Frequency of Occult High-Grade Squamous Intraepithelial Neoplasia and Invasive Cancer within Anal Condylomata in Men Who Have Sex with Men

Author: Hans P. Schlecht, Dana K. Fugelso, Ryan K. Murphy, Katiri T. Wagner, John P. Doweiko, JoAnn Proper, Bruce J. Dezube, and Lori A. Panther

pp. 117-126

Excess Mortality in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy: Temporal Changes and Risk Factors

Authors: Milo A. Puhan, Mark L. Van Natta, Frank J. Palella, Adrienne Addessi, and Curtis Meinert, for the Studies of the Ocular Complications of AIDS Research Groupa

pp. 127-129

Editorial Commentary: Perspectives on the Role of Immunization against Influenza in HIVInfected Patients

Authors: Raphael Dolin

pp. 130-139

Sex, Race, and Geographic Region Influence Clinical Outcomes Following Primary HIV-1 Infection

Authors: Amie L. Meditz, Samantha MaWhinney, Amanda Allshouse, William Feser, Martin Markowitz, Susan Little, Richard Hecht, Eric S. Daar, Ann C. Collier, Joseph Margolick, J. Michael Kilby, Jean-Pierre Routy, Brian Conway, John Kaldor, Jay Levy, Robert Schooley, David A. Cooper, Marcus Altfeld, Douglas Richman, and Elizabeth Connick

pp. 140-141

Editorial Commentary: Gender, Race, and Geography: Do They Matter in Primary Human Immunodeficiency Virus Infection?

Authors: Wendy S. Armstrong and Carlos del Rio

pp. 142-149

Update on Human Immunodeficiency Virus (HIV)-2 Infection

Authors: Omobolaji T. Campbell-Yesufu, and Rajesh T. Gandhi

pp. 150-157

Men Who Have Sex With Men, Risk Behavior, and HIV Infection: Integrative Analysis of Clinical, Epidemiological, and Laboratory Databases

Authors: Itzchak Levy, Zohar Mor, Emilia Anis, Shlomo Maayan, Eyal Leshem, Shimon Pollack, Michal Chowers, Orna Mor, Klaris Riesenberg, Zev Sthoeger, Daniela Ram, and Zehava Grossman

pp. 158-160